Cheeky Logo
Ready To Get Hired?
Apply To Book A Free Call With Our Transition Specialist Team

What Is Open Innovation And Why It’s The Future Of The Biotech Industry

There were many reasons why I chose to leave academia and transition into industry.

At the time, I could not care less which company I worked for or what the company stood for.

Should I work at a start-up, or at a big pharma company?

Should I work in R&D at the bench, or as an analyst away from the bench?

Who cares?

Just give me a job.

I wanted out of academia and I wanted out yesterday.

It wasn’t until much later that I realized how important it was to think strategically about what companies I should target during my job search and why.

During my first industry interview, I met with the CEO of a start-up company and we began to ‘talk shop,’ or talk about current industry trends.

But I had no idea how to talk shop.

I knew nothing about the CEO’s company structure, the current landscape of their market, or where the company or the biotechnology field in general was heading in the next 5-10 years.

So, I just smiled and nodded.

I had nothing to say.

I couldn’t even think of a relevant question to ask.

It was a wasted opportunity.

I began to set up informational interviews with other industry professionals and soon learned that it was in my best interests to know what happens ‘behind the scenes’ in industry.

As I set up more and more interviews, I learned about things like mergers and acquisitions.

I learned about internal restructurings.

I learned about things like organizational behavior, business ethics, and company culture.

Over time, I realized that I wanted to choose a company to work for that knew where the market was heading and how their company would stay relevant.

I wanted to work for a company that had staying power and would still be in business 5-10 years down the road.

I took all of this as a wake-up call and prioritized staying up-to-date on current industry trends.

By the time my next industry interview and site visit came along, I was prepared.

During the interview, I was able to communicate intelligently about the company’s structure and management activities.

What Is Open Innovation And Why PhDs Should Care

In the last decade, the biotechnology and biopharmaceutical sectors have been influenced by a number of new advancements leading to a major shift in the culture of innovation.

Financial pressure, growing cost of innovation, and increased competition from emerging markets has pushed industries to look for new ways to reduce cost while sustaining innovation.

As a result, there has been a shift toward an Open Innovation (OI) model versus a traditional, or closed, R&D model.

OI is where organizations look outside the confines of their own capabilities to source ideas, technologies, and intellectual property (IP) in order to boost their R&D success rate.

In a major contrast to a traditional closed model of innovation, OI favors more extensive sharing of IP and R&D capabilities between collaborating organizations.

An analysis by the consulting firm Deloitte on innovation models in industry found that large industry organizations pursuing an OI model were 3X more likely to achieve late-stage success in product development compared to those relying on a traditional, or closed, innovation model.

Imagine walking into an interview and being able to intelligently discuss why open innovation is a positive cultural shift for the company you’re applying to and to the biotechnology and biopharmaceutical industries as a whole.

The hiring managers on the other side of the table would be both surprised and impressed.

Their preconceived notions of you being a narrow-minded academic with no business knowledge would immediately vanish and, as a result, you would be in the driver’s seat for the rest of the interview.

Why Open Innovation Is Expanding In Industry

A better understanding of complex biological processes over the last two decades has made it possible for companies to innovate faster and with a relatively smaller infrastructure.

Breakthroughs that were only possible through a massive venture over a long period of many years by very large organizations can now be done by smaller institutions in a fraction of the time.

Knowing how and why this trend is occurring is an important part of positioning yourself as a top job candidate in industry.

Knowledge of OI and why OI is expanding, along with deep knowledge of other current industry trends, will help you get hired over other job candidates.

Here are 4 reasons why open innovation is expanding in the biotech and biopharma sectors…

1. An increase in patents expirations.

A large number of so-called blockbuster drugs have either reached or are about to reach the end of their patent terms.

As a result, more and more generic drugs are capturing this blockbuster market share.

According to a report by EvaluatePharma, between 2015 and 2020, the total value of revenue at risk as a result of patent expiry is expected to be around US $197 billion.

Noticeable inclusions in this list are Bristol-Myers Squibb/Otsuka Pharmaceutical’s antipsychotic drug Abilify and the insulin treatment Lantus from Sanofi.

GlaxoSmithKline’s cardiovascular medication Lovaza already saw launch of its generic version.

According to industry experts, the combined revenue loss of the top 10 selling drugs will add up to US $32 billion globally.

To compensate for this loss, the biopharmaceutical industry is placing a renewed focus on the development of new drugs.

To reduce time and cost of developing these new drugs, these companies are increasingly forming alliances, participating in mergers and acquisitions, and depending more and more on external innovation.

To shield themselves from revenue loss caused by generics in the future, decision-makers at these companies have become increasingly interested in highly innovative therapies.

Especially therapies that are difficult or impossible to replicate (even after patent expiration), including gene therapy and personalized medicine innovations.

The trend to innovate unreplicable therapies is spurred by collaboration through an OI model with reputed academic institutions.

For example, according to a report by Tufts University’s Center for Study of Drug Development (CSDD), research alliances between academic organizations and industry partners in the immuno-oncology therapeutic area grew by 10-fold in only two years.

This trend is expected to continue over the next 5-10 years.

2. Growing cost of R&D in big pharma.

Recent surveys have shown that large pharmaceutical organizations have to spend $1-2 billion to bring a single drug successfully to market.

These expenses far exceed the expenses incurred in any other sector of industry.

For example, on a percent of revenue basis, Apple’s annual investment in R&D is only ~12.5% of Merck’s annual investment in R&D.

In spite of increased spending in R&D, the number of new molecular entities receiving regulatory approval from the FDA has not significantly increased over the last 60 years.

A major portion of R&D expenditure comes from initial exploratory research that often does not lead to the desired result.

While essential, this exploratory research yields a very low return on investment.

Obtaining innovations from external sources, such as smaller biotech organizations which can afford to have more cost-effective infrastructure, is a viable solution to this.

Setting up strategic alliances with academic labs that focus on exploratory research is another viable solution.

Rather than investing in robust in-house R&D projects, biotechnology and biopharmaceutical companies can form partnerships with universities and acquire a technology after years and years of basic research that has been done in academic labs.

Altogether, establishing strategic alliances to develop an effective OI model enables large pharmaceutical organizations to close gaps in their in-house R&D capabilities in a cost-effective fashion.

3. More stringent regulatory approval process.

Another factor forcing large organizations to design a better innovation model and focus on R&D has been the toughening of approval parameters.

It’s becoming increasingly hard for large industry institutions to secure approval for both drugs and diagnostics unless they are significantly better or demonstrate technological advancement over existing products.

As a result, so-called “me-too” therapies are less likely to get regulatory approval.

A study published in Nature in 2014 evaluated clinical trials and FDA approval data of about 4,500 drugs over an 8-year period. The findings of the study indicated that the rate of investigational drugs successfully transitioning from Phase I to final FDA approval is only about 10%.

This has forced stakeholders in the biopharma sector to look for new ways to boost innovation, acquire new ideas, and expand their portfolios in cutting-edge therapies such as gene therapy or drug-antibody conjugates.

Once again, implementing OI and fostering more extensive collaboration has proven to be the most cost-effective way of sustaining cutting-edge innovations. 

In the last two years, drug approvals granted by the FDA have gone up as a result of more drugs being based on novel mechanisms.

Chemical & Engineering News reported that 42% of drugs receiving regulatory approval from the FDA are based on novel mechanisms.

About 30% of these new approvals were for novel biologics and 16 out of a total of 45 approved drugs demonstrated a completely new mechanism of action.

Innovation and novelty are essential for accomplishing regulatory approval and ensuring continued growth of any pharmaceutical organization.

4. Change in public sector funding.

While the biotechnology and biopharmaceutical industries struggle with R&D costs, funding for academic research through government-run agencies continues to decline.

As just one example, in 2013 the NIH funded 722 less projects than in 2012.

Only ~16% of grant applications were successful by the end of 2013.

In addition to these funding challenges, there’s been a shift in the kinds of projects that are getting funded.

Funding patterns indicate that academic projects with translational value, such as those aligned towards developing therapies and improving medicine, have a much higher chance of getting funded.

As a result, academic researchers are now more likely to explore partnerships with biotechnology and biopharmaceutical companies.

A recent survey across 50 academic medical research centers found that out of the 3,000 researchers questioned, the majority were involved in industry-academia collaborative projects.

Likewise, biotech and biopharma companies are more likely to find academic research projects that align with the industry’s main purpose of developing medicinal products.

In addition, the Journal of the American Medical Association reported that biotech and biopharma companies spend 25-30% more on research than on NIH funding.

These biotech and pharma companies need external collaborations to control escalating R&D costs.

R&D in the biotechnology and biopharmaceutical industries is changing faster than ever before. Medical breakthroughs are happening more frequently and financial pressure and a highly competitive environment has forced major players in this sector to adapt in order to keep up. For PhDs wanting to transition out of academia, it is pivotal to know how these trends apply to the companies you are applying to and, more importantly, be able to discuss them with confidence and ease during networking events and interviews. By combining this knowledge of current industry trends with your already well-established technical skill set, you will be the perfect job candidate.

If you’re ready to start your transition into industry, you can apply to book a free Transition Call with our founder Isaiah Hankel, PhD or one of our Transition Specialists. Apply to book a Transition Call here.

Book a Transition Call
Get Free Job Search Content Weekly

ABOUT ARUNODOY SUR, PHD

Arunodoy is a Ph.D. in Integrative Biology and has training in intellectual property, entrepreneurship, and venture capitalism. He also has experience with global biotechnology and biopharmaceutical companies, including clinical trial consulting. Arunodoy is passionate about the translation of academic research to the real world and commercialization of scientific innovation so that it can help solve problems and benefit people. He possesses in-depth understanding of both technological and commercial aspects associated with the life science industry.

Arunodoy Sur, PhD

Here's What Others Are Saying

"I have been quiet here for a while but happy to finally share that I've transitioned! It was a long and challenging journey towards transition, being at another full-time job plus being a toddler mom, but I am so thankful I found this supportive community that has helped me and motivated me throughout."

Shobana Sekar

Shobana Sekar

Senior Bioinformatics Scientist

at Roche

"I'm happy to share that I will be starting a new position as MSL at Sanofi! I want to thank everyone that took the time to speak with me about their MSL experience and to help me land this position!"

John Crawford

John Crawford

MSL-Vaccines

at Sanofi

"I'm happy to share that I'm stating a new position as Medical Science Liaison at Celltrion Healthcare Co, Ltd.!"

Tammy Virdi

Tammy Virdi

MSL

at Celltrion Healthcare Co, Ltd

"Hi Isaiah, I got hired yesterday!....Thanks for all of your encouragement provided by way of your presentations."

Beverly Brereton

Beverly Brereton

Compliance Manager

at Enel North America

"I am delighted to announce that I have accepted the role of Research Scientist with a base salary of 90k. The cheeky scientist resources have helped me immensely and I am really grateful."

Amninder Singh Sekhon

Amninder Singh Sekhon

Research Scientist

"I attended the Transition CHALLENGE and VIP Modality and, as a result, in less than 2 months I have participated in 8 interesting interviews and been offered a wonderful job full of opportunities! Thank you so much for all the great and necessary work you do!"

Veronica Pascual

Veronica Pascual

Research Projects Coordinator

at SEMERGEN

"I signed with ASML for 117k! (asked for 120 and they came up from 110) plus a 10% target annual bonus."

Andrew Dawes, PhD

Andrew Dawes, PhD

Senior Applications Engineer

at ASML

"I'm happy to share that I'm starting a new position as Clinical Scientist at Arvinas!"

Ana Luiza C. Zaninotto

Ana Luiza C. Zaninotto

Clinical Scientist

at Arvinas

"A new chapter begins! I'm thrilled to launch Wenwirth Scientific, where sincere meets creativity with a mission to make medical communication more engaging, impactful, and effective. I am ready to bring game-changing ideas to help you unleash the power of words and medicine. Many thanks to those who have supported me in this journey, I can't wait to work with you and start serving the healthcare community and patients."

Huey Wen Lee

Huey Wen Lee

Creative Medical Communications

at Wenworth Scientific

"I’m happy to share that I started a new position as Medical Science Liaison at Ashfield this January, part of UDG Healthcare (now Inizio) supporting Avita Medical. Thank you to all my mentors, colleagues, and friends who have been incremental in making this dream possible for me.....It is an exciting space/time and I can’t wait for the future."

Mimi Borrelli

Mimi Borrelli

Medical Science Liaison

at Inizio

"Thank you for your support. I greatly benefited from your DD talks on the importance of networking on LinkedIn and resume-building tips. Your team member Meera was very helpful in building my LinkedIn Profile and resume. Thank you!"

 Taranum Sultana

Taranum Sultana

Research Administration

"I am happy to share that I'm starting a new position as a European Portfolio Manager at Scientific Instruments!"

 Shikha Acharya

Shikha Acharya

European Portfolio Manager

at Scientific Instruments

"I’m excited to share that i am starting my new job as a technical support engineer at lumencor, inc. the ultimate goal is to grow potatoes on mars by 2050 and make other advaces for mankind."

 Andrii Repula

Andrii Repula

Technical Support Engineer

at Lumencor, Inc.

"I accepted my job offer today. I was able to get 5k more + the exact PTO package I wanted. I am very happy and very thankful for everything that I learned through the event. I plan to stay involved with Cheeky Scientist as I love what y'all are doing and I'm still learning."

Tracy Gardner, PhD

Tracy Gardner, PhD

Senior Measurement Advisor

at Pearson

"I picked the Planet job! It ended up being the better fit for me... Thanks for all of your help!"

Emily Martin

Emily Martin

Hardware Systems Engineer

at Planet

Similar Articles

Why PhDs Are Mentally Tough (& How They Use It To Get Hired)

Why PhDs Are Mentally Tough (& How They Use It To Get Hired)

By: Isaiah Hankel, PhD

“Isaiah, I’m at my wit’s end.  I’ve applied to countless jobs, networked extensively, and still, nothing.  It feels like I’m just spinning my wheels.”  This is a sentiment I hear often from PhDs who are navigating the challenging waters of the job market.  The frustration and mental fatigue are real, especially when you’re used to achieving high levels of success in academia.  But let’s get one thing straight – you are not alone, and this is not the end.  It’s just a bump in the road.  Yes, the job search is grueling.  There’s no sugar-coating it.  But here’s the thing…

3 Entry-Level PhD Jobs Pay Six Figures A Year

3 Entry-Level PhD Jobs Pay Six Figures A Year

By: Isaiah Hankel, PhD

I was determined to stay in academia… until I wasn’t.  It took almost six years for me to reach the conclusion that academia just wasn’t for me.  My PhD defense was just a few months away, and I can’t lie: I was literally willing myself to stick it out. But what about after that? Professorship had been the goal for me before I ever even enrolled in college. It had been my dream. I had absolutely no idea what to do if it wasn’t going to teach. I knew what I didn’t want: I didn’t want to be tethered to…

5 Positions In Biopharma Perfect For Any PhD

5 Positions In Biopharma Perfect For Any PhD

By: Isaiah Hankel, PhD

It was by chance that I even considered a career in biopharma.  As far as I was concerned, academia was all there was. The world of industry was a big question mark to me, and that was fine. I found myself working on a postdoc, waiting for a tenure-track position to open up.  At first, it was exciting: a real, paying job as a PhD-level scientist. I showed up early, stayed late, and was happy to do it.  But a change happened, gradually. There was so much repetition in my day, and so much emphasis on performing tasks that required…

Top 5 Industry Career Tracks For PhDs

Top 5 Industry Career Tracks For PhDs

By: Isaiah Hankel, PhD

From the time I started graduate school, there was only one point in the future that I could focus on: the finish line. I was swept up in my own expectations and also caught up in what I thought was expected of me. But something I hadn’t given much thought to was what I actually wanted to do. I was about six months away from defending my thesis. That’s when I started to give some serious thought to what would happen after I added the “Dr.” to my name. It’s when I began to admit to myself that academia was…

Spin The Hard Knocks Of Academia To Your Advantage To Get Hired

Spin The Hard Knocks Of Academia To Your Advantage To Get Hired

By: Isaiah Hankel, PhD

Something that comes up a lot when I talk to new PhDs is that they think they don’t have enough on-the-job experience to apply for the high earning jobs they’re perfect for. I see this imposter syndrome prevent PhDs from even trying to apply for jobs – and puts a stop to their journey to getting hired in industry. So they settle.  For academia, where they don’t have job security.  For jobs that pay less and don’t value their abilities.  For a job they’re not interested in and don’t want, but they think it gets them “started” in industry when…

6 Rewarding Careers In Research Policy, Funding & Government

6 Rewarding Careers In Research Policy, Funding & Government

By: Isaiah Hankel, PhD

An indomitable spirit is a rare quality, but not among PhDs. Perseverance is a prerequisite that comes standard with every doctorate.  It seems like there’s no shortage of things that can stand in the way when you’re pursuing a terminal degree. Yet I’ve only met a handful of PhDs who weren’t cut out for the hardships of academia. They made it past the gauntlet of frustrating academic advisors, endless hours in the lab, and year upon year of compounding stress. But there are some things that arise that you simply can’t prepare yourself to push through. Sometimes life happens. PhDs…

Best Of Transition: Ph.D. Jobs & Job Search Strategies January 7, 2023

Best Of Transition: Ph.D. Jobs & Job Search Strategies January 7, 2023

By: Isaiah Hankel, PhD

Every week, we at Cheeky Scientist scour the Internet for the best articles on topics that help in the search for the Best of Transition: PhD Job Search in the industry. Our two consultants independently search for the most informative articles in the categories of networking, CVs/resumes, interviews, transferable skills, academic blues, industry positions, and business acumen. Our consultants vote on a top article for each category and a top overall article for the week – if it’s a recent article that can help readers find and acquire PhD jobs, then we want to include it in this weekly digest.…

4 Red-Hot Intellectual Property Positions For PhDs

4 Red-Hot Intellectual Property Positions For PhDs

By: Isaiah Hankel, PhD

I just got off the phone with an old friend of mine.  We were researchers at the same lab back in our university days. We had lost touch, but when he found me on LinkedIn I couldn’t wait to hear what he’s done since graduation.  He told me he had not wound up in chemistry, which had been his major. Biomolecular chemistry, he reminded me. Instead, he decided to pursue a career in patent law.  Here’s his transition story: I was in the process of earning my PhD in biomolecular chemistry. That’s where I learned that patents were unrecognized by…

4 Oddly Popular PhD Careers In Finance And Business

4 Oddly Popular PhD Careers In Finance And Business

By: Isaiah Hankel, PhD

PhDs in the sciences and humanities are not qualified to work in finance or business. At least that’s what I thought. That was until I started hearing more of my former colleagues talk about their transition into consulting and financial service roles. These were people who specialized in very niche areas of science. I was surprised to learn that their skills were needed in the financial and business sectors of industry. What can a PhD in the sciences or humanities possibly contribute to finance and business? As always, it comes down to your transferable skills. These sectors are seeking highly…

Our Members Get Hired At Top Industry Companies

Top Industry Career eBooks

63 Best Industry Positions For PhDs

63 Best Industry Positions For PhDs

Isaiah Hankel, PhD & Arunodoy Sur, PhD

Learn about the best 63 industry careers for PhDs (regardless of your academic background). In this eBook, you will gain insight into the most popular, highest-paying jobs for PhDs – all of which will allow you to do meaningful work AND get paid well for it.

Industry Resume Guide for PhDs

Industry Resume Guide for PhDs

Isaiah Hankel, PhD

Learn how to craft the perfect industry resume to attract employers. In this eBook for PhDs, you will get access to proven resume templates, learn how to structure your bullet points, and discover which keywords industry employers want to see most on PhD resumes.

AI & ATS Resume Filters

AI & ATS Resume Filters

Isaiah Hankel

In today's competitive job market, understanding the impact of AI is crucial for career success. This involves ensuring your resume stands out in the digital realm, mastering your online presence, and being aware of how AI assigns reputation scores. Discovering how to leverage AI to your advantage is essential, as it plays a pivotal role in shaping professional opportunities.

Complete LinkedIn Guide For PhDs

Complete LinkedIn Guide For PhDs

Isaiah Hankel

The LinkedIn tips & strategies within have helped PhDs from every background get hired into top industry careers.